Antihistamines and Dry Eyes: What You Should Know

Antihistamines are commonly used medications for managing allergies, but they can have unintended side effects, particularly concerning eye health. One of the most significant side effects associated with antihistamines is the development of dry eyes. Understanding this relationship is crucial for effective allergy management and overall comfort.


Antihistamines work by blocking the action of histamine, a substance in the body that causes allergic symptoms like sneezing, itching, and congestion. While they are effective in alleviating these symptoms, they can also inhibit the production of natural tears, leading to dryness in the eyes.


Dry eyes may manifest as a burning or stinging sensation, redness, and increased sensitivity to light. For some individuals, this condition can be particularly bothersome, impacting daily activities and overall quality of life. Therefore, it’s essential to be aware of the potential for dry eyes when using antihistamine medications.


There are two primary types of antihistamines: first-generation and second-generation. First-generation antihistamines, such as diphenhydramine (Benadryl), are more likely to cause dry eyes due to their sedative effects and their ability to cross the blood-brain barrier. In contrast, second-generation antihistamines, like loratadine (Claritin) and cetirizine (Zyrtec), tend to cause fewer side effects and are generally less likely to contribute to eye dryness.


If you notice symptoms of dry eyes while taking antihistamines, consider the following strategies to manage this side effect:


  • Opt for Second-Generation Antihistamines: Consult your healthcare provider about switching to second-generation antihistamines, which may present a lower risk of causing dry eyes.
  • Use Artificial Tears: Over-the-counter artificial tears can provide relief from dryness and help maintain proper eye moisture.
  • Maintain Hydration: Drinking plenty of water can help support overall hydration, which is vital for maintaining tear production.
  • Avoid Environmental Irritants: Minimize exposure to smoke, dust, and other irritants that can exacerbate dry eyes.
  • Consult an Eye Care Professional: If dry eye symptoms persist, seeking guidance from an eye care specialist may be necessary for tailored treatment options.

It's important to balance allergy relief with the potential side effects of antihistamines. Communicating with your healthcare provider about your symptoms can lead to better management strategies. For individuals suffering from allergies, being proactive about eye health can lead to a more comfortable and effective treatment experience.


In summary, while antihistamines are effective for controlling allergy symptoms, they can contribute to dry eyes. By understanding this relationship and adopting strategies to mitigate dry eye symptoms, individuals can maintain eye health while effectively managing their allergies.